CardioTarget

Heart-failure cardiomyocyte atlas — a cross-disease / cross-species signature → target-prioritization resource.

MetaTarget · CardioTarget · Home Tables Scorecard Drivers Cross-disease Drugs Gene lookup

Start with a gene.

Look up any gene to see its heart-failure evidence — per-disease effect sizes, druggability, conservation, and whether it’s an upstream driver. Or explore the prioritized shortlist below.

New here? Looking up a gene is the quickest way in — then follow the links on its evidence card.

How CardioTarget is built — the logic in five steps
1Many HF cohorts cross-disease & cross-species snRNA-seq of cardiomyocytes
2Cross-disease signature meta-analysis → the shared effector genes that change
3Upstream drivers the master-regulator TFs controlling that program
4Prioritize & tractability rank by druggability, genetics, structure (CADD), conservation
5Drug repurposing compounds predicted to reverse the signature
Popular starting points
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Prioritization scorecard

The ranked shortlist — top candidates with every evidence sub-score shown at a glance.

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Cross-disease overlap

Which heart-failure diseases share which signature genes — an interactive UpSet view.

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Upstream drivers

The master-regulator TFs behind the signature, scored across five convergence axes.

More to explore
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Drug repurposingreversers of the signature
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Structural druggabilityAlphaFold + fpocket (CADD)
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Gene target dossiereffect · driver · causal · spatial, one page
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All data tablesbrowse & search everything
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MetaTarget Analyzerun it on your own data
Mechanism & validation
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De-maturation decompositionfetal-program reactivation in the signature
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Driver → effector mechanismhow driver TFs control effector genes
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Chromatin validationsnATAC driver-motif enrichment in disease DARs
Causal anchor (W2)public TF-perturbation corroboration of drivers
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Spatial nominationdriver regulons + niche in human-MI tissue