Small molecules predicted to reverse the heart-failure cardiomyocyte signature (connectivity / LINCS L1000).
MetaTarget · CardioTarget · Home Tables Scorecard Drivers Cross-disease Drugs Gene lookup
Reversal = a compound whose transcriptional effect opposes the disease signature. Mechanistic prior flags anti-remodeling classes as favorable and chronic cAMP-raisers as cautionary (transcriptional reversal ≠ therapeutic benefit). “Consensus” = found by both L1000CDS2 and DrugReflector.